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April 1, 2002Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Role of ADP Receptor P2Y12in Platelet Adhesion and Thrombus Formation in Flowing Blood

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Why the study?

What is the role of the P2Y12 receptor in platelet adhesion and thrombus formation under physiological flow?

Population

Blood from a patient with a defect in the gene encoding P2Y12 and from healthy volunteers

Comparison

P2Y12 antagonist or P2Y1 antagonist added to… vs Control blood from healthy volunteers without…

Design

Preclinical

Authors

JRJasper A. RemijnMeander Medisch CentrumYWYaping WuDalian Medical UniversityEJEllen H. JeningaTergooi

Discussion

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Implication

The P2Y12 receptor is essential for normal thrombus buildup on collagen and platelet adhesion on fibrinogen under physiological flow.

Structured PICO

What is the role of the P2Y12 receptor in platelet adhesion and thrombus formation under physiological flow?

P
Population
Blood from a patient with a defect in the gene encoding P2Y12 and from healthy volunteers
I
Intervention
P2Y12 antagonist (AR-C69931 MX) or P2Y1 antagonist (adenosine-3',5'-diphospate) added to control blood, and blood from a P2Y12-deficient patient
C
Comparator
Control blood from healthy volunteers without antagonists
O
Outcome
Platelet adhesion and thrombus formation under physiological flow on collagen-coated coverslips and immobilized fibrinogensurrogate

The P2Y12 receptor is essential for normal thrombus buildup on collagen and platelet adhesion on fibrinogen under physiological flow.

Cite This Study

Remijn et al. (2002) studied this question.

synapsesocial.com/papers/6a81b489f453150ffdd81fc3https://doi.org/10.1161/01.atv.0000012805.49079.23

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules1986 · 174 citations
  2. 2Axial Dependence of Collagen–Induced Thrombus Formation in Flowing Non-Anticoagulated Human Blood1995 · 17 citations
  3. 3Clopidogrel – a Platelet Inhibitor which Inhibits Thrombogenesis in Non-Anticoagulated Human Blood Independently of the Blood Flow Conditions1994 · 59 citations
  4. 4Platelet Thrombus Formation on Collagen at High Shear Rates Is Mediated by von Willebrand Factor–Glycoprotein Ib Interaction and Inhibited by von Willebrand Factor–Glycoprotein IIb/IIIa Interaction2000 · 79 citations
  5. 5Role of Glycoprotein IIb:IIIa in the Adhesion of Platelets to Collagen Under Flow Conditions1997 · 9 citations