Why the study?
Does P2Y12 receptor blockade reduce embolus and thrombus formation in an in vivo rabbit model of arterial injury?
Population
Anesthetized rabbits with mechanically injured mesenteric arterioles
Comparison
Selective P2Y12 antagonists AR-C69931 MX (3… vs Control (implied)
Design
Preclinical
Authors
Loading...
P2Y12 blockade attenuates embolization in rabbit arterial injury; extends mechanistic insights but leaves open human translation.
Does P2Y12 receptor blockade reduce embolus and thrombus formation in an in vivo rabbit model of arterial injury?
In vivo blockade of the P2Y12 receptor reduces thrombus growth and embolus formation without compromising initial plug stability, providing mechanistic insight into its benefits in arterial thrombosis.
Gestel et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: