Why the study?
Does P2Y12 receptor stimulation enhance procoagulant activity and thrombin generation in platelets?
Population
Platelet-rich plasma from healthy subjects, young patients with stroke or type-II diabetes, and older stroke…
Design
Preclinical
Authors
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Animal data implicate P2Y12 in ADP-driven thrombin generation; leaves open human validation for thrombogram-based clopidogrel monitoring.
Does P2Y12 receptor stimulation enhance procoagulant activity and thrombin generation in platelets?
P2Y12 receptor stimulation by ADP amplifies phosphatidylserine exposure and thrombin generation via a novel Ca2+ signaling pathway, highlighting the role of P2Y12 in procoagulant activity and the utility of thrombograms for measuring clopidogrel efficacy.
Meijden et al. (2005) studied this question.
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