What question did this study set out to answer?

To characterize the biochemical properties of the adenosine diphosphate (ADP) inactivating system in platelet-poor plasma and assess its activity across different clinical states.

January 1, 1964Thrombosis and Haemostasis

Investigation on Adenosine Diphosphate (ADP) Induced Platelet Adhesiveness in Vitro Part III. The Inactivation of ADP in Plasma

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Authors

AÖA. E ÖdegaardOslo University Hospital BSB. A. SkålheggOslo University Hospital AHA. J. HellemOslo University Hospital

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Implication

In vitro ADP inactivation properties defined; leaves open any role in thrombosis or altered platelet function in metabolic disease.

Key Points

To characterize the biochemical properties of the adenosine diphosphate (ADP) inactivating system in platelet-poor plasma and assess its activity across different clinical states.
Assessed temperature stability, dialysability, and the inhibitory effects of potassium cyanide, cysteine, 2,3-dimercaptopropanol, and penicillamine (2–5 × 10⁻³ M) on plasma ADP inactivation.
Measured ADP inactivation capacity in platelet-poor plasma from healthy subjects and patients with thyrotoxicosis, diabetes mellitus, hypercholesterolemia, and bleeding disorders.
The ADP-inactivating system exhibited peak activity at approximately 37°C, was non-dialysable, and was irreversibly inactivated by heating at 58°C for 15 minutes.
Inactivation of ADP was markedly increased in plasma from patients with thyrotoxicosis compared to healthy controls and other diseased cohorts.

Cite This Study

Ödegaard et al. (1964) studied this question.

synapsesocial.com/papers/6a75c1ed3dd558469eb93456 https://doi.org/10.1055/s-0038-1654832

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Investigation on Adenosine Diphosphate (ADP) Induced Platelet Adhesiveness in Vitro Part III. The Inactivation of ADP in Plasma

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Cite This Study

Investigation on Adenosine Diphosphate (ADP) Induced Platelet Adhesiveness in Vitro Part III. The Inactivation of ADP in Plasma

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Cite This Study

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