Population
Platelets in citrated and heparinized plasma (in vitro)
Comparison
Adenosine Diphosphate at concentrations between… vs Various concentrations of citrate and heparin…
Design
Preclinical
Authors
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Caution against clinical extrapolation from in vitro ADP-platelet data; leaves open mechanistic questions for in vivo thrombosis models.
In vitro platelet adhesiveness is logarithmically proportional to ADP concentration and is highly sensitive to temperature and platelet washing conditions.
Hellem et al. (1963) studied this question.
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