Key result
Addition of adenosine diphosphate to citrated blood caused an initial increase in platelet adhesiveness for 15 minutes, followed by a decrease and subsequent steady increase.
The study demonstrates a biphasic response of platelet adhesiveness to ADP, emphasizing the need for standardized timing in platelet function assays.
May require timed platelet assays; leaves open standardization and human translation.
Platelet adhesiveness to glass beads was measured in citrated blood at intervals up to two hours after the addition of adenosine diphosphate (A.D.P.). Adhesiveness increased for 15 minutes, fell towards the original level, and then steadily increased. The initial changes were associated with the formation and subsequent dispersal of platelet clumps. The sequence of events resembled the reported platelet aggregation, the disaggregation and secondary aggregation effect of A.D.P. and emphasizes the importance of a standard technique in the measurement of A.D.P.-induced platelet adhesiveness.
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Bloom et al. (1967) studied this question. Adenosine diphosphate (A.D.P.) was evaluated on Platelet adhesiveness to glass beads. Addition of adenosine diphosphate to citrated blood caused an initial increase in platelet adhesiveness for 15 minutes, followed by a decrease and subsequent steady increase.
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