Key result
Genetic deletion of GPER abolished sex differences in pulse wave velocity, whereas female wild-type mice uniquely adapted to hypertension by increasing wall thickness.
Why the study?
Arterial stiffness increases after menopause, suggesting estrogen may be protective, and previous work indicated GPER mediates estrogen's vascular actions.
Does genetic deletion of GPER attenuate sex differences in pulse wave velocity and vascular mechanics in mice?
Population
Male and female wild-type and GPER knockout mice, control and Ang II-infused
Comparison
GPER knockout vs wild-type and Ang II infusion vs control across sexes
Design
Preclinical animal study
Authors
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GPER deletion abolishes sex differences in PWV and LV mass in hypertensive mice; hypothesis-generating for sex-specific vascular mechanics but should not yet change practice.
Does genetic deletion of GPER attenuate sex differences in pulse wave velocity and vascular mechanics in mice?
Female mice exhibit unique vascular adaptation to hypertension via increased wall thickness, highlighting the potential clinical utility of intracarotid PWV assessment in women beyond standard blood pressure measurements.
Ogola et al. (2021) studied Vascular stiffness. Genetic deletion of GPER and Angiotensin II infusion vs. Wild-type and control conditions was evaluated on Pulse wave velocity (PWV) and left ventricular mass. Genetic deletion of GPER abolished sex differences in pulse wave velocity, whereas female wild-type mice uniquely adapted to hypertension by increasing wall thickness.
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