Key result
Higher interleukin-6 levels were independently associated with an increased risk of first-ever cerebrovascular events (HR 1.80 per 1-SD increase in log IL-6, P=0.03).
Why the study?
Do elevated IL-6 levels and silent lacunar infarction predict first-ever cerebrovascular events in outpatients with vascular risk factors?
Cohort (n=464)
Do elevated IL-6 levels and silent lacunar infarction predict first-ever cerebrovascular events in outpatients with vascular risk factors?
Hazard Ratio: 1.8
p-value: p=0.03
Elevated IL-6 levels are independently associated with first-ever cerebrovascular events and improve risk reclassification in patients with silent lacunar infarction.
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May enhance cerebrovascular risk stratification in outpatients with silent lacunar infarcts; extends IL-6 data but remains hypothesis-generating.
Miwa et al. (2012) conducted a cohort in Vascular risk factors without preexisting cardiovascular disease (n=464). Interleukin-6 (IL-6) levels vs. Lower IL-6 levels was evaluated on First-ever cerebrovascular events (CVEs) (HR 1.80, p=0.03). Higher interleukin-6 levels were independently associated with an increased risk of first-ever cerebrovascular events (HR 1.80 per 1-SD increase in log IL-6, P=0.03).