Why the study?
The study explored the association between depressive symptoms and non-fatal cardiovascular disease, along with other risk factors, in middle-aged and elderly patients with hypertension in China.
Are depressive symptoms associated with an increased risk of non-fatal cardiovascular disease in middle-aged and elderly patients with hypertension?
Population
1755 middle-aged and elderly patients with hypertension aged 45 and above in China
Comparison
Varying levels of depressive symptoms
Design
Prospective cohort study
Follow-up
9-year period
Key result
Severe depressive symptoms significantly increased the risk of non-fatal cardiovascular disease by 67% (HR 1.67) compared to no depressive symptoms in middle-aged and elderly patients with hypertension.
Authors
Loading...
Depressive symptoms may identify higher-risk hypertensive patients; leaves open whether intervention reduces non-fatal CVD events.
Cohort (n=1,755)
Yes
Are depressive symptoms associated with an increased risk of non-fatal cardiovascular disease in middle-aged and elderly patients with hypertension?
Hazard Ratio: 1.67 (95% CI 1.37–2.02)
Depressive symptoms have a graded, positive linear correlation with incident non-fatal cardiovascular disease in middle-aged and elderly Chinese patients with hypertension.
Xie et al. (2025) conducted a cohort in Hypertension (n=1,755). Severe depressive symptoms vs. No depressive symptoms was evaluated on Non-fatal cardiovascular disease (HR 1.67, 95% CI 1.37 to 2.02). Severe depressive symptoms significantly increased the risk of non-fatal cardiovascular disease by 67% (HR 1.67) compared to no depressive symptoms in middle-aged and elderly patients with hypertension.