Highly sensitive: The hyper-Rayleigh Scattering (HRS) technique has been used to achieve the ultrasensitive detection of single base-pair mismatches in oligonucleotide strands without any modification of DNA. A very distinct HRS intensity change is observed after hybridization even at the concentration of 10-nanomolar probe single-stranded DNA.
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Paresh Chandra Ray (2006) studied this question.
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