Key result
In aortic stenosis, myocardial hypertrophy and focal fibrosis progress without intervention; after aortic valve replacement, cellular hypertrophy regresses but focal scar remains irreversible.
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Myocardial tissue characterization by CMR provides critical insights into the transition from adaptive hypertrophy to irreversible focal scar in aortic stenosis, which may help optimize the timing of valve replacement.
Treibel et al. (2018) conducted an editorial in Aortic Stenosis. In aortic stenosis, myocardial hypertrophy and focal fibrosis progress without intervention; after aortic valve replacement, cellular hypertrophy regresses but focal scar remains irreversible.
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