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June 1, 1983Annals of the New York Academy of Sciences

The Structure of Fibrinogen and Fibrin: Ii. Architecture of the Fibrin Clot*

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Population

Fibrinogen and fibrin molecules/microcrystals

Design

Preclinical

Authors

JWJohn W. WeiselUniversity of PennsylvaniaCCCarolyn CohenBrandeis University

Discussion

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Overview

Informs molecular packing in fibrin clots; leaves open translation to human antithrombotic strategies pending validation.

Structured PICO

P
Population
Fibrinogen and fibrin molecules/microcrystals
I
Intervention
Structural analysis using electron microscopy and x-ray diffraction
O
Outcome
Molecular packing and structure of the fibrin clot

This structural analysis provides a low-resolution model of fibrinogen and fibrin, revealing the molecular packing and protofibril arrangement critical for clot formation.

Cite This Study

Weisel et al. (1983) studied this question.

synapsesocial.com/papers/6a7dc40ba76b9ebabb045471https://doi.org/10.1111/j.1749-6632.1983.tb23257.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Fine Structure of Fibrin1967 · 75 citations
  2. 2The Cross Striation Pattern of the Fibrin Fibril1970 · 20 citations
  3. 3The Fibrinogen Molecule: Its Size, Shape, and Mode of Polymerization1959 · 550 citations