Key result
Acute mental stress triggers central autonomic hyper-reactivity in hypertensive rats across early and established disease.
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The hypothalamic defence reaction was assessed in spontaneously hypertensive rats (SHR) and normotensive control rats (NCR). 2. SHR exhibited an apparently true hyper-reactivity of central autonomic structures mediating emotional behaviour during mental stress present in early as well as in established hypertension. 3. This hyper-reactivity is thought, therefore, to be a genetically linked factor predisposing to hypertension in SHR, rather than a consequence of the hypertensive state.
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Folkow et al. (1973) studied Spontaneous hypertension in rats. Acute mental stress vs. Normotensive control rats (NCR) was evaluated on Hypothalamic defence reaction and central autonomic hyper-reactivity. Acute mental stress elicited hyper-reactivity of central autonomic structures in spontaneously hypertensive rats compared with normotensive controls during both early and established hypertension.
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