Key result
Angiotensin 1-7 generally exerts a renoprotective effect by improving endothelial function and counteracting angiotensin II-induced damage, although its actions can vary depending on specific kidney conditions.
Angiotensin 1-7 appears to exert renoprotective effects primarily by improving endothelial function and antagonizing the deleterious actions of Angiotensin II, highlighting its potential therapeutic relevance in renal hemodynamics.
Supports targeted research on angiotensin 1-7 in kidney disease; should not yet change clinical practice.
The two important arms of renin angiotensin system (RAS) are angiotensin II (Ang II) and angiotensin1-7 (Ang1-7). Both of these peptides are present in the kidney, while the renal hemodynamic responses to these peptides act differently in kidney circulation. For this short-review, we used a variety of sources including PubMed, Google Scholar, and Scopus. Although in normal physiological condition, Ang1-7 has been known as an inactive agent in the renal system, however in past years many experimental and clinical reports indicated the protective role of Ang1-7 in renal hemodynamics and functions under different circumstances. In the current article, the possible renoprotective role of Ang1-7 was briefly reviewed.
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Mehdi Nematbakhsh (2018) conducted a review in Kidney injury. Angiotensin 1-7 was evaluated. Angiotensin 1-7 generally exerts a renoprotective effect by improving endothelial function and counteracting angiotensin II-induced damage, although its actions can vary depending on specific kidney conditions.
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