Self‐Liganded Suzuki–Miyaura Coupling for Site‐Selective Protein PEGylation

Building with PEGs: PEG–boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70–98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands.