Key result
Acromegaly is associated with significantly increased maximum left atrial volumes (78.7 vs 44.8 mL, P<.05) and altered left atrial functional properties compared to healthy subjects.
Why the study?
Does acromegaly alter left atrial volumetric and functional properties as measured by 3DSTE compared to healthy controls?
Case-Control (n=40)
Does acromegaly alter left atrial volumetric and functional properties as measured by 3DSTE compared to healthy controls?
Absolute Event Rate: 78.7% vs 44.8%
p-value: p=<.05
Acromegaly is associated with significantly increased left atrial volumes and altered functional deformation properties as measured by 3D speckle tracking echocardiography.
Supports LA monitoring in acromegaly; leaves open whether 3DSTE indices predict outcomes or guide therapy.
INTRODUCTION: Acromegaly is a chronic and disfiguring hormonal disease caused by a benign growth hormone-secreting pituitary adenoma in most of the cases. The objective of this study was to investigate three-dimensional (3D) speckle tracking echocardiography (3DSTE)-derived left atrial (LA) volumetric and functional properties in patients with acromegaly. It was also examined whether the activity of acromegaly is associated with further alterations in these LA parameters. METHODS: A total of 23 patients with acromegaly were involved in this study. Due to inadequate image quality, 4 patients were excluded from the 3DSTE analysis. The mean age of the remaining acromegalic subjects was 58.5 ± 13.1 years (7 males). The control group consisted of 21 age- and gender-matched healthy subjects (mean age 51.8 ± 10.3 years, 10 males). RESULTS: Maximum (44.8 ± 12.7 mL vs 78.7 ± 25.4 mL, P < .05), minimum (24.1 ± 9.0 mL vs 44.5 ± 15.5 mL, P < .05), and preatrial contraction (35.5 ± 11.2 mL vs 66.0 ± 22.8 mL, P < .05) LA volumes were significantly different between all acromegaly patients compared with controls. Increased peak global and mean segmental radial and 3D strains and decreased LA circumferential strain (CS) could be detected in all acromegaly patients as compared to healthy subjects. Significant correlation could be detected between insulin-like growth factor 1 (IGF-1) index and peak superior LA-CS (r = .49, P = .05) in acromegaly. CONCLUSION: Acromegaly is associated with increased LA volumes and changes in LA functional properties.
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Kormányos et al. (2018) conducted a case-control in Acromegaly (n=40). Acromegaly vs. Healthy subjects was evaluated on Maximum left atrial volume (mL) (p=<.05). Acromegaly is associated with significantly increased maximum left atrial volumes (78.7 vs 44.8 mL, P<.05) and altered left atrial functional properties compared to healthy subjects.
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