What question did this study set out to answer?

To compare the pharmacokinetic profiles of meropenem administered via continuous infusion versus intermittent administration in critically ill patients.

April 1, 1999Journal of Antimicrobial Chemotherapy

Continuous infusion versus intermittent administration of meropenem in critically ill patients

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Authors

FTFlorian ThalhammerUniversitätszahnklinik Wien FTFriederike TraunmüllerStatistics Austria IMIbrahim El MenyawiCSL (Switzerland)

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Implication

Randomized trial demonstrates sustained protective antibiotic levels with continuous meropenem infusion in critically ill patients, indicating its suitability alongside intermittent dosing.

Key Points

To compare the pharmacokinetic profiles of meropenem administered via continuous infusion versus intermittent administration in critically ill patients.
Prospective randomized crossover trial in 15 critically ill patients.
Patients received either continuous infusion (2 g intravenous loading dose followed by 3 g over 24 hours) or intermittent administration (2 g intravenously every 8 hours) for 2 days before crossing over to the alternate regimen for 2 days.
Continuous infusion resulted in a steady-state concentration (Css) of 11.9 ± 5.0 mg/L and an AUC of 117.5 ± 12.9 mg/L·h.
Intermittent administration resulted in a Cmax of 110.1 ± 6.9 mg/L, Cmin of 8.5 ± 1.0 mg/L, total clearance of 9.4 ± 1.2 L/h, and a significantly larger AUC compared to continuous infusion (P < 0.001).
Both dosing regimens maintained serum meropenem concentrations above the minimum inhibitory concentrations for common bacterial pathogens throughout the treatment periods.

Cite This Study

Thalhammer et al. (1999) studied this question.

synapsesocial.com/papers/6a7dccfa77b363cb17b87694 https://doi.org/10.1093/jac/43.4.523

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Implication

Randomized trial demonstrates sustained protective antibiotic levels with continuous meropenem infusion in critically ill patients, indicating its suitability alongside intermittent dosing.

Continuous infusion versus intermittent administration of meropenem in critically ill patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Continuous infusion versus intermittent administration of meropenem in critically ill patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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