What question did this study set out to answer?

To evaluate the mechanism of metformin on glucose production and tissue-specific glucose utilization in insulin-resistant obese (fa/fa) rats.

September 15, 1989Biochemical JournalOpen Access

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine

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Authors

LPLuc PénicaudCentre National de la Recherche Scientifique YHY HitierRoche (Switzerland)PFPascal FerréInserm

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Implication

Animal study demonstrates enhanced intestinal glucose utilization after oral metformin in obese rats, highlighting the digestive tract's primary role in blood sugar clearance.

Key Points

To evaluate the mechanism of metformin on glucose production and tissue-specific glucose utilization in insulin-resistant obese (fa/fa) rats.
Administered oral metformin daily for 8 days to female genetically obese (fa/fa) rats.
Measured glucose turnover, recycling, and tissue utilization in anesthetized, post-absorptive rats 5 hours after the final dose.
Metformin treatment increased whole-body glucose production and utilization by 1.5-fold.
Enhanced glucose production was driven almost entirely by increased glucose recycling.
The digestive tract was identified as the sole tissue responsible for the increased glucose utilization.

Cite This Study

Pénicaud et al. (1989) studied this question.

synapsesocial.com/papers/6a7dcd541b4d300315045bc1 https://doi.org/10.1042/bj2620881

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Implication

Animal study demonstrates enhanced intestinal glucose utilization after oral metformin in obese rats, highlighting the digestive tract's primary role in blood sugar clearance.

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine

Discussion

Member takes

Implication

Key Points

Cite This Study

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