Why the study?
Does the OAS1 splice site polymorphism influence susceptibility to type 1 diabetes?
Population
835 type 1 diabetic patients and 401 healthy siblings
Comparison
OAS1 splice site polymorphism (A/G SNP) genotype vs Healthy siblings / different genotypes
Design
Case-control
Authors
Loading...
Should not change clinical practice; leaves open whether OAS1 variants causally influence type 1 diabetes susceptibility.
Does the OAS1 splice site polymorphism influence susceptibility to type 1 diabetes?
The OAS1 splice site polymorphism is associated with susceptibility to type 1 diabetes, suggesting host genetic response to virus infection plays a role.
Field et al. (2005) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: