What question did this study set out to answer?

To evaluate the association between remnant cholesterol levels and the onset of diabetes mellitus across different age and sex groups.

October 27, 2025Journal of Diabetes InvestigationOpen Access

Effect of remnant cholesterol on the onset of diabetes mellitus

View Full Paper

Ask AI

Bookmark

Authors

TMTeruki MiyakeEhime University Hospital SFShinya FurukawaEhime University AKAyumi KanamotoEhime University

Discussion

Member takes

Implication

Retrospective cohort study reveals an association between elevated remnant cholesterol and diabetes mellitus onset in adults under 50, highlighting the potential value of age-specific screening.

Key Points

To evaluate the association between remnant cholesterol levels and the onset of diabetes mellitus across different age and sex groups.
Retrospective cohort study of 13,952 participants with two or more health checkups between April 2003 and March 2021 in Japan, with a mean follow-up of 4.66 years.
Multivariate Cox proportional hazard models assessed diabetes onset risk stratified by sex and age (<50 vs. ≥50 years), comparing remnant cholesterol against triglycerides.
Elevated remnant cholesterol significantly associated with diabetes onset in individuals <50 years among men (aHR = 1.81, 95% CI: 1.46–2.20) and women (aHR = 2.13, 95% CI: 1.18–3.37).
Remnant cholesterol showed no statistically significant association with diabetes onset in adults aged ≥50 years.
Triglyceride levels also predicted diabetes onset in younger adults, displaying a slightly higher predictive ability (AUC) than remnant cholesterol, especially in younger women.

Cite This Study

Miyake et al. (2025) studied this question.

synapsesocial.com/papers/6a7dce57fcc540eda03c93a6 https://doi.org/10.1111/jdi.70163

View Full Paper

Ask AI

Bookmark

October 27, 2025Journal of Diabetes InvestigationOpen Access

Effect of remnant cholesterol on the onset of diabetes mellitus

View Full Paper

Ask AI

Bookmark

Authors

TMTeruki MiyakeEhime University Hospital SFShinya FurukawaEhime University AKAyumi KanamotoEhime University

Discussion

Member takes

Implication

Retrospective cohort study reveals an association between elevated remnant cholesterol and diabetes mellitus onset in adults under 50, highlighting the potential value of age-specific screening.

Key Points

To evaluate the association between remnant cholesterol levels and the onset of diabetes mellitus across different age and sex groups.
Retrospective cohort study of 13,952 participants with two or more health checkups between April 2003 and March 2021 in Japan, with a mean follow-up of 4.66 years.
Multivariate Cox proportional hazard models assessed diabetes onset risk stratified by sex and age (<50 vs. ≥50 years), comparing remnant cholesterol against triglycerides.
Elevated remnant cholesterol significantly associated with diabetes onset in individuals <50 years among men (aHR = 1.81, 95% CI: 1.46–2.20) and women (aHR = 2.13, 95% CI: 1.18–3.37).
Remnant cholesterol showed no statistically significant association with diabetes onset in adults aged ≥50 years.
Triglyceride levels also predicted diabetes onset in younger adults, displaying a slightly higher predictive ability (AUC) than remnant cholesterol, especially in younger women.

Cite This Study

Miyake et al. (2025) studied this question.

synapsesocial.com/papers/6a7dce57fcc540eda03c93a6 https://doi.org/10.1111/jdi.70163

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark