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January 13, 2012American Journal of Respiratory Cell and Molecular BiologyOpen Access

Periostin, a Matricellular Protein, Plays a Role in the Induction of Chemokines in Pulmonary Fibrosis

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Population

Periostin-deficient mice, lung fibroblasts, and lung tissue from patients with idiopathic pulmonary fibrosis…

Comparison

Bleomycin administration and TNF-α stimulation vs Control mice and control fibroblasts

Design

Preclinical

Authors

MUMasaru UchidaKurume UniversityHSHiroshi ShiraishiKeio UniversitySOShoichiro OhtaUniversity of Southern California

Discussion

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Implication

Hypothesis-generating for periostin blockade in interstitial lung disease; requires human validation before clinical consideration.

Structured PICO

P
Population
Periostin-deficient mice, lung fibroblasts, and lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and chemotherapeutic-agent-induced interstitial lung disease (ILD)
I
Intervention
Bleomycin administration (in vivo) and TNF-α stimulation (in vitro)
C
Comparator
Control mice and control fibroblasts
O
Outcome
Pulmonary fibrosis and chemokine productionsurrogate

Periostin mediates pulmonary fibrosis by inducing chemokines that recruit inflammatory cells, highlighting it as a potential therapeutic target for interstitial lung disease.

Cite This Study

Uchida et al. (2012) studied this question.

synapsesocial.com/papers/6a7dcf1009233241edac78f4https://doi.org/10.1165/rcmb.2011-0115oc
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Also Consider

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  1. 1Periostin is essential for cardiac healingafter acute myocardial infarction2008 · 470 citations
  2. 2Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells2008 · 139 citations
  3. 3Predictive Factors for Interstitial Lung Disease, Antitumor Response, and Survival in Non–Small-Cell Lung Cancer Patients Treated With Gefitinib2006 · 363 citations
  4. 4Neutralization of the CXC Chemokine, Macrophage Inflammatory Protein-2, Attenuates Bleomycin-Induced Pulmonary Fibrosis1999 · 249 citations
  5. 5Integrins: roles in cancer development and as treatment targets2004 · 578 citations