Key result
Periostin deficiency in mice impaired cardiac healing after acute myocardial infarction, resulting in cardiac rupture due to reduced myocardial stiffness and impaired collagen fibril formation.
Why the study?
Does periostin mediate cardiac healing and prevent cardiac rupture after acute myocardial infarction?
Population
Human and mouse hearts with acute myocardial infarction, specifically including a generated periostin…
Comparison
Gene transfer of a spliced form of periostin… vs Wild-type mice; unrescued periostin(-/-) mice
Design
Preclinical
Authors
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Hypothesis-generating in mice; leaves open periostin’s therapeutic role in human post-MI healing and rupture prevention.
Does periostin mediate cardiac healing and prevent cardiac rupture after acute myocardial infarction?
Periostin is essential for cardiac healing after acute myocardial infarction by promoting the recruitment of activated fibroblasts and collagen fibril formation via FAK-integrin signaling.
Shimazaki et al. (2008) studied Acute myocardial infarction. Periostin gene knockout and gene transfer was evaluated on Cardiac healing and cardiac rupture. Periostin deficiency in mice impaired cardiac healing after acute myocardial infarction, resulting in cardiac rupture due to reduced myocardial stiffness and impaired collagen fibril formation.
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