Why the study?
Does periostin ablation inhibit post-infarction myocardial regeneration in neonatal mice?
Population
Neonatal periostin-knockout mice and wildtype littermates subjected to myocardial infarction or sham…
Comparison
Periostin ablation (knockout) vs Wildtype mice (normal periostin expression)
Design
Preclinical
Follow-up
Up to 21 days
Authors
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Periostin ablation impairs neonatal post-MI regeneration; leaves open its role in adult repair and any therapeutic potential.
Does periostin ablation inhibit post-infarction myocardial regeneration in neonatal mice?
Periostin is essential for post-infarction myocardial regeneration in neonatal mice, acting via the PI3K/GSK3β/cyclin D1 signalling pathway.
Chen et al. (2017) studied this question.
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