Key result
Cardiac fibroblast periostin expression increases after MI, peaking at day 7 before declining by day 14.
Why the study?
The timing of periostin upregulation in cardiac fibroblasts after myocardial infarction was not fully elucidated, limiting optimal targeting of periostin-producing cells for therapy.
p-value: p=<0.05
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Early post-MI periostin upregulation in murine fibroblasts should not change practice; leaves open its role in human remodeling.
Gil et al. (2022) studied Acute myocardial infarction. Surgical myocardial infarction (LAD ligation) vs. Healthy mice (no MI) was evaluated on Periostin gene and protein cellular expression timeline (p=<0.05). Following surgical myocardial infarction in mice, periostin gene and protein expression in cardiac fibroblasts increased significantly during days 2-7, peaking at day 7 and declining by day 14.
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