Key result
Post-MI periostin elevation strongly correlates with reduced fractional area change in a rat model.
Why the study?
The role of periostin in chronic cardiac remodeling after myocardial infarction remains to be elucidated.
Effect estimate: r = -0.783
p-value: p=0.008
In a rat model of myocardial infarction, tissue periostin levels correlated with adverse structural and functional cardiac remodeling at 3 months.
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May warrant preclinical follow-up on periostin in remodeling; leaves open any clinical biomarker or therapeutic role pending human data.
Minicucci et al. (2013) studied Myocardial infarction (n=21). Myocardial infarction induction vs. Simulated surgery (SHAM) was evaluated on Correlation between periostin and fractional area change (r = -0.783, p=0.008). In a rat model, myocardial infarction induced higher periostin levels that inversely correlated with fractional area change (r = -0.783, p = 0.008) and posterior wall shortening velocity.
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