Key result
Post-MI periostin expression in murine cardiac fibroblasts peaks at day 7 before declining.
Why the study?
Prior studies suggesting periostin as a candidate therapeutic target for post-MI fibrosis did not properly address the time dependency between periostin activity and cardiac fibrosis.
Periostin expression peaks at day 7 post-myocardial infarction in mice, providing a specific temporal window for targeted gene therapy against cardiac fibrosis.
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Animal models link post-MI remote fibrosis to structural deterioration; leaves open therapeutic relevance in patients.
Gil et al. (2022) studied Acute Myocardial Infarction and Cardiac Fibrosis. Surgical myocardial infarction (LAD ligation) vs. Healthy, non-infarcted myocardium was evaluated on Timeline of periostin gene and protein expression in infarcted cardiac tissue. Following acute myocardial infarction in mice, periostin expression in cardiac fibroblasts increased significantly from day 2 to day 7, peaking at day 7 before declining by day 14.
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