Why the study?
Does esmolol improve heart rhythm stabilization in a patient with dilated cardiomyopathy and electrical storm refractory to amiodarone?
Does esmolol improve heart rhythm stabilization in a patient with dilated cardiomyopathy and electrical storm refractory to amiodarone?
Esmolol may be an effective rescue therapy for cardiac electrical storm in patients with dilated cardiomyopathy when standard therapies like amiodarone fail.
May support esmolol rescue in amiodarone-refractory electrical storm; hypothesis-generating and leaves open need for trials in dilated cardiomyopathy.
The present study reports a case of electrical storm occurring in a 43-year-old woman with dilated cardiomyopathy. The patient suffered from a cardiac electrical storm, with 98 episodes of ventricular tachycardia rapidly degenerating to ventricular fibrillation in hospital. The patient was converted with a total of 120 defibrillations. Recurrent ventricular tachycardia/fibrillation was initiated by premature ventricular beats. The patient did not respond to the use of amiodaronum. However, the administration of esmolol stabilized the patient's heart rhythm. A moderate dose of the β-blocker esmolol, administered as an 0.5-mg intravenous bolus injection followed by an infusion at a rate of 0.15 mg/kg/min, inhibited the recurrence of ventricular fibrillation and normalized the electrocardiographic pattern. The results suggest that esmolol may be able to improve the survival rate of patients with electrical storm in dilated cardiomyopathy and should be considered as a primary therapy in the management of cardiac electrical storms.
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Li et al. (2016) studied this question.
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