Key result
Treatment for depression or anxiety with psychotropic drugs was not independently associated with an increased risk of acute myocardial infarction compared to no treatment (HR 0.96).
Why the study?
Reported associations between depression and myocardial infarction might be explained by psychotropic drug use, residual confounding, or reverse causation, warranting investigation in UK women without previous vascular disease.
Does treatment for depression or anxiety increase the risk of myocardial infarction in women without prior vascular disease?
Population
690 335 UK women with no prior heart disease, stroke, transient ischaemic attack, or cancer
Comparison
Treatment for depression or anxiety (with or without psychotropic drugs) vs not
Design
Prospective cohort study
Follow-up
Mean 13.9 years
Authors
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Null findings after adjustment support no independent MI risk from depression; leaves open residual confounding or reverse causation in other groups.
Cohort (n=690,335)
Yes
Does treatment for depression or anxiety increase the risk of myocardial infarction in women without prior vascular disease?
Hazard Ratio: 0.96 (95% CI 0.89–1.03)
In a large prospective cohort of UK women, depression and anxiety were not found to be independent risk factors for myocardial infarction.
Parkin et al. (2021) conducted a cohort in Acute myocardial infarction (n=690,335). Treatment for depression or anxiety (with psychotropic drugs) vs. No treatment for depression or anxiety and no use of psychotropic drugs was evaluated on First hospital admission or death from acute myocardial infarction (HR 0.96, 95% CI 0.89-1.03). Treatment for depression or anxiety with psychotropic drugs was not independently associated with an increased risk of acute myocardial infarction compared to no treatment (HR 0.96).
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