Population
Rat strains with salt-aggravated hypertension (Dahl-S and SHR)
Comparison
8% dietary NaCl vs Baseline/normal diet; NG-nitro-L-arginine (in SHR)
Design
Preclinical
Authors
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Differential renal TZR responses in SHR versus Dahl-S models indicate independent genetic control; leaves open translation to human salt-sensitive hypertension.
The renal response to NaCl-induced increases in blood pressure can be genetically modulated independently of the genes mediating primary hypertension or salt sensitivity.
Fanestil et al. (1999) studied this question.
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