A novel murine model of arrhythmogenic cardiomyopathy reveals that a desmoglein-2 nonsense mutation leads to structural defects, reduced Wnt/β-catenin signaling, and specific miRNA dysregulation.
Should not yet inform clinical management of arrhythmogenic cardiomyopathy; extends mechanistic insights via a novel desmoglein-2 murine model.
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Calore et al. (2018) studied this question.
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