September 11, 2014Cardiovascular ResearchOpen Access

Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function

View Full Paper

Ask AI

Bookmark

Population

HL-1 cardiomyocytes and murine Langendorff hearts

Comparison

Modulation of desmoglein-2 interaction vs Control conditions (e.g., L-phenylalanine)

Design

Preclinical

Authors

ASAngela SchlippLudwig-Maximilians-Universität München CSCamilla SchinnerUniversity of Bern VSVolker SpindlerUniversität Hamburg

Discussion

Member takes

Implication

Murine desmoglein-2 disruption impairs cardiomyocyte function; hypothesis-generating for arrhythmogenic cardiomyopathy mechanisms and requires human validation before any clinical consideration.

Structured PICO

Population

HL-1 cardiomyocytes and murine Langendorff hearts

Intervention

Modulation of desmoglein-2 interaction (via L-tryptophan, desmoglein-specific peptides, Ca2+-depletion, knockdown, mutations, or overexpression)

Comparator

Control conditions (e.g., L-phenylalanine)

Outcome

Cardiomyocyte cell-cell cohesion and functionsurrogate

Desmoglein-2 plays a critical role in cardiomyocyte cohesion and mechanical function, providing mechanistic insights relevant to arrhythmogenic cardiomyopathy.

Cite This Study

Schlipp et al. (2014) studied this question.

synapsesocial.com/papers/6a7dd45614e877b18fa1480c https://doi.org/10.1093/cvr/cvu206

View Full Paper

Ask AI

Bookmark

Implication

Murine desmoglein-2 disruption impairs cardiomyocyte function; hypothesis-generating for arrhythmogenic cardiomyopathy mechanisms and requires human validation before any clinical consideration.

Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider