Prognostic Value of Plasma Big Endothelin-1 in Patients Hospitalized for Heart Failure
Why the study?
Does elevated plasma big ET-1 predict cardiovascular death in patients hospitalized for heart failure?
Population
4,368 hospitalized HF patients
Comparison
Plasma big ET-1 levels evaluated continuously and by tertiles
Design
Single-center retrospective cohort study
Follow-up
Median 875 (365-1,400) days
Authors
Discussion
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Member takes
Implication
Big ET-1 may aid HF prognostication; hypothesis-generating and requires prospective validation before clinical use.
Structured PICO
Does elevated plasma big ET-1 predict cardiovascular death in patients hospitalized for heart failure?
P
Population
4,368 hospitalized heart failure patients (de novo, worsening, or chronic included) in a single-center retrospective cohort
I
Intervention
Elevated plasma big Endothelin-1 (big ET-1) levels
C
Comparator
Lower plasma big ET-1 levels (analyzed as continuous variable and by tertiles)
O
Outcome
Cardiovascular deathhard clinical
Elevated plasma big ET-1 is an independent predictor of cardiovascular death in hospitalized heart failure patients, offering incremental prognostic value when combined with NT-proBNP.
Cite This Study
Wang et al. (2025) studied this question.