Activation of volume-sensitive chloride channels plays a major role in mediating doxorubicin-induced cell shrinkage and apoptosis in adult cardiomyocytes.
No takes yet. Share an insight, caveat, or question.
I(Cl,vol) inhibition may mitigate doxorubicin cardiotoxicity in cardiomyocytes; leaves open in vivo translation and clinical testing.
Tassigny et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: