Maximally helical polyalanines, 9 to 24 residues in length, are used to calibrate the assignment of fractional helicity (FH) from circular dichroism ellipticities. Water-solubilizing, helix-stabilizing N- and C-caps induce FHs>0.9 in core polyalanine regions. Linear length regressions of peptide molar ellipticities (blue-green curves) yield slopes (red arrows) that define molar per-residue ellipticities of a fully helical alanine residue (red curve).
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Job et al. (2004) studied this question.
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