Why the study?
Second-generation antipsychotics are used for mental disorders and carry cardiometabolic side effects in children, prompting assessment of cardiovascular health in SGA-treated and SGA-naive children with mental disorders.
Does second-generation antipsychotic treatment alter cardiovascular structure and function in children with mental disorders compared to SGA-naive children and healthy controls?
Does second-generation antipsychotic treatment alter cardiovascular structure and function in children with mental disorders compared to SGA-naive children and healthy controls?
Children with mental disorders exhibit greater arterial stiffness and altered cardiac structure/function compared to healthy controls, but second-generation antipsychotic treatment itself is not associated with further alterations in these cardiovascular parameters despite increased cardiometabolic risk factors.
Answers are grounded in this paper and cite their sources.
Children with mental disorders warrant CV monitoring regardless of SGA use; leaves open causal effects of antipsychotics on arterial stiffness.
Objective: Second-generation antipsychotics (SGAs) are used for a variety of mental disorders and are associated with cardiometabolic side effects in children. The objective of this study was to assess the cardiovascular health of children with mental disorders that are SGA-treated or SGA-naive. Methods: SGA-treated ( n = 47) or SGA-naive ( n = 37) children (aged 6 to 18 years) with mental disorders and control children ( n = 83, no mental disorder) underwent assessment for cardiac function and morphology by echocardiography, aortic pulse wave velocity (PWV), and carotid intima-media thickness (cIMT). Body mass index (BMI) z-scores, waist circumference z-scores, systolic and diastolic blood pressure (BP) percentiles for height and sex, and fasting plasma glucose, insulin, triglycerides, and cholesterol were also assessed. Differences between SGA-treated, SGA-naive, and control children were assessed by linear and log-linear regression models. Results: SGA-treated children had greater BMI z-scores and overweight/obesity (BMI ≥ 85th percentile for age and sex) and hypertension than SGA-naive and control children. The PWV geometric mean was 11.1% higher in SGA-treated (95%CI, 3.95 to 18.77) and 12.9% higher in SGA-naive children (95% CI, 5.60 to 20.59) compared to controls in models adjusted for age, sex, BMI, and systolic BP percentile. Left ventricular (LV) end-diastolic dimension/body surface area (BSA), LV end-systolic dimension/BSA, and LV ejection fraction were lower in SGA-treated and SGA-naive children compared to controls in models adjusted for sex and age. Conclusions: Children with mental disorders have greater arterial stiffness and altered cardiac structure/function than children with no mental health diagnosis. SGA treatment in children is not associated with alterations in cardiovascular structure/function.
No takes yet. Share an insight, caveat, or question.
Henderson et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: