What question did this study set out to answer?

To examine the effects of 8 weeks of high-intensity exercise training on sarcolemmal lactate and hydrogen ion transport, monocarboxylate transporter expression, and muscle metabolite release during exhaustive exercise.

February 1, 1999AJP Endocrinology and Metabolism

Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle

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Authors

HPHenriette PilegaardUniversity of Copenhagen KDKristian DominoUniversity of Copenhagen TNThomas D. NolandUniversity of Copenhagen

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Implication

Experimental exercise trial demonstrates increased muscle lactate transport capacity in humans, indicating improved cellular acid-clearing efficiency during exertion.

Key Points

To examine the effects of 8 weeks of high-intensity exercise training on sarcolemmal lactate and hydrogen ion transport, monocarboxylate transporter expression, and muscle metabolite release during exhaustive exercise.
Human participants completed an 8-week unilateral knee-extensor high-intensity exercise training protocol.
Biopsies were collected from trained and untrained vastus lateralis muscles to quantify sarcolemmal giant vesicle transport rates (n = 7) and MCT1 and MCT4 transporter protein contents (n = 4).
Sarcolemmal lactate/H+ transport rate was 12% higher (P < 0.05, n = 7) in trained muscle compared with untrained muscle.
Trained muscle exhibited 76% higher MCT1 and 32% higher MCT4 protein content (n = 4).
Release rates of lactate and H+ were similar between legs at exhaustion, but intracellular-to-interstitial gradients of lactate and H+ were significantly lower in trained muscle (P < 0.05).

Cite This Study

Pilegaard et al. (1999) studied this question.

synapsesocial.com/papers/6a7ddc5e2d182a3d7e99ab9d https://doi.org/10.1152/ajpendo.1999.276.2.e255

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Implication

Experimental exercise trial demonstrates increased muscle lactate transport capacity in humans, indicating improved cellular acid-clearing efficiency during exertion.

Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle

Discussion

Member takes

Implication

Key Points

Cite This Study

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