September 5, 2013Chinese Medical JournalOpen Access

Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy

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Why the study?

Does the measurement of IL-27, IFN-γ, and ADA in pleural effusion improve the diagnostic accuracy for tuberculous pleurisy?

Population

81 patients with pleural effusion

Comparison

Measurement of pleural and serum concentrations… vs Comparison between tuberculous and…

Design

Cross-sectional

Authors

YWYanbin WuZhejiang Chinese Medical University ZYZhijian YeCentral South University SQSou-ming QINUnion Hospital

Discussion

Member takes

Implication

IL-27 shows promise for TPE diagnosis in pleural fluid; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does the measurement of IL-27, IFN-γ, and ADA in pleural effusion improve the diagnostic accuracy for tuberculous pleurisy?

Population

81 patients with pleural effusion (40 with tuberculous pleural effusion, 26 with malignant pleural effusion, 7 with infectious pleural effusion, and 8 with transudative pleural effusion)

Intervention

Measurement of pleural and serum concentrations of interleukin-27 (IL-27), interferon-γ (IFN-γ), and adenosine deaminase (ADA)

Comparator

Comparison between tuberculous and non-tuberculous (malignant, infectious, transudative) pleural effusions

Outcome

Diagnostic accuracy (sensitivity and specificity) for differentiating tuberculous pleural effusion from other etiologiessurrogate

The combination of IL-27, IFN-γ, and ADA in pleural effusion provides highly accurate diagnosis of tuberculous pleurisy, with IL-27 alone showing excellent diagnostic performance.

Cite This Study

Wu et al. (2013) studied this question.

synapsesocial.com/papers/6a7ddc6333dcb27c99cb5e12 https://doi.org/10.3760/cma.j.issn.0366-6999.20130020

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Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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