September 1, 1989Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access
Immune mechanisms in atherosclerosis.
Population
Rats with experimental arterial balloon injury
Comparison
Cyclosporin A vs Controls
Design
Review
Authors
Discussion
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Implication
May implicate T-cell modulation in post-injury vascular remodeling; leaves open translation to human atherosclerosis or restenosis.
Structured PICO
P
Population
Rats with experimental arterial balloon injury (as part of a broader review on immune mechanisms in atherosclerosis)
I
Intervention
Cyclosporin A
C
Comparator
Controls
O
Outcome
Intimal lesion sizesurrogate
T cell activation and cytokines may play a significant role in modulating the vascular response to injury and local lipid metabolism in atherosclerotic plaques.
Limitations
- Cyclosporin A could exert unknown nonimmune vascular effects
- Cell proliferation in human atherosclerotic plaques may not be as high as in experimental animal lesions
Cite This Study
Göran K. Hansson (1989) studied this question.