Why the study?
Does pretreatment with fosinopril or valsartan reduce myocardial no-reflow in a swine model of acute myocardial infarction and reperfusion?
Population
56 mini-swine subjected to an acute myocardial infarction and reperfusion model.
Comparison
Pretreatment with fosinopril or valsartan for 3… vs Control group, sham-operated group, and groups…
Design
Preclinical, randomized into seven study groups
Follow-up
2-h reperfusion
Authors
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Should not change clinical practice; leaves open whether pretreatment reduces no-reflow in human AMI.
Does pretreatment with fosinopril or valsartan reduce myocardial no-reflow in a swine model of acute myocardial infarction and reperfusion?
Pretreatment with fosinopril or valsartan significantly reduces myocardial no-reflow and necrosis size following acute myocardial infarction and reperfusion in a swine model, mediated by KATP channel activation.
Zhao et al. (2006) studied this question.
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