January 1, 2002Japanese Heart JournalOpen Access

Effects of Cilazapril on Endothelial Function and Pulmonary Hypertension in Patients with Congestive Heart Failure.

View Full Paper

Ask AI

Bookmark

Why the study?

Does cilazapril improve endothelial function and pulmonary hypertension in patients with congestive heart failure and coronary artery disease?

Population

30 consecutive patients diagnosed with coronary artery disease and congestive heart failure.

Design

Cohort, Image analysis performed by one observer who had no knowledge of the…

Follow-up

3 days

Authors

TTTalat TavlıIzmir University HGHakan GöçerBalikli Rum Vakfi Hastanesi

Discussion

Member takes

Implication

Should not yet change practice in CHF with CAD; leaves open whether cilazapril improves endothelial function and pulmonary pressures.

Structured PICO

Does cilazapril improve endothelial function and pulmonary hypertension in patients with congestive heart failure and coronary artery disease?

Population

30 consecutive patients (16 males, 14 females, mean age 65±18) diagnosed with coronary artery disease (documented with coronary angiography) and congestive heart failure (documented left ventricular systolic and diastolic dysfunction, NYHA III-IV functional capacity).

Intervention

Cilazapril 5 mg/day for 3 days (Note: Methods state 3 days, though Discussion mentions 3 months).

Outcome

Flow-mediated vasodilation (FMD), brachial artery flow, brachial artery diameter, and hemodynamic parameters (mean pulmonary artery pressure, pulmonary capillary wedge pressure, left ventricular ejection fraction).surrogate

Short-term cilazapril administration significantly improved endothelium-dependent vasodilation and reduced pulmonary pressures in patients with congestive heart failure and coronary artery disease.

Limitations

Further dose ranging and time course studies are required with different drugs

Cite This Study

Tavlı et al. (2002) studied this question.

synapsesocial.com/papers/6a7c7a0d502bfbc401fd6399 https://doi.org/10.1536/jhj.43.667

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Effects of Cilazapril on Endothelial Function and Pulmonary Hypertension in Patients with Congestive Heart Failure.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Effects of Cilazapril on Endothelial Function and Pulmonary Hypertension in Patients with Congestive Heart Failure.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider