Why the study?
Does denopamine relieve symptoms in a patient with refractory variant angina?
Does denopamine relieve symptoms in a patient with refractory variant angina?
Denopamine may be an effective therapeutic agent for severe variant angina, suggesting that adrenergic beta-1 receptors play an important role in coronary spasm.
May warrant trial of denopamine in refractory variant angina; single case is hypothesis-generating and should not alter practice.
A 48-year-old man with severe variant angina refractory to conventional treatment with calcium antagonists and nitrates, or prazosin, or trihexyphenidyl hydrochloride, became symptom free rapidly when treated with denopamine, a adrenergic beta-1 agonist. Denopamine may prove to be an additional therapeutic agent in the management of severe variant angina. Therefore the response to denopamine and the lack of response to prazosin in this patient suggests that not only the adrenergic alpha receptor but also the adrenergic beta-1 receptor plays an important role in the production of coronary spasm, at least in some patients.
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Shimizu et al. (1991) studied this question.
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