Why the study?
Does nNOS inhibition reduce blood pressure in eNOS null mutant mice?
Population
eNOS null mutant, wild-type, and heterozygous mice, as well as +/+ mice with renovascular hypertension.
Comparison
Acute administration of selective nNOS inhibitor… vs Baseline blood pressure and responses in…
Design
Preclinical
Follow-up
Acute (up to 2 hours) and chronic (4 weeks)
Authors
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nNOS inhibition may lower BP in eNOS deficiency; hypothesis-generating for compensatory NO signaling, no clinical implications.
Does nNOS inhibition reduce blood pressure in eNOS null mutant mice?
In the absence of eNOS activity, NO derived from nNOS paradoxically increases blood pressure both acutely and chronically.
Kurihara et al. (1998) studied this question.
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