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June 24, 2025Frontiers in Public HealthOpen Access

Individuals in the highest depression severity group experienced a 2.02-fold higher risk of heart disease compared to the reference group, but showed a reduced risk of stroke (OR 0.759) and no significant difference in mental illness risk (OR 0.924, p=0.513).

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Why the study?

Mental health problems, especially depression, are linked to chronic diseases, but the dose-response relationship between depression severity, chronic disease risks, and interactive effects on cognitive outcomes required investigation in middle-aged and older Chinese adults.

Does depression severity increase the risk of heart disease, stroke, and mental illness in Chinese middle-aged and older adults?

Population

13,930 participants aged 45 and above from CHARLS

Comparison

Depression symptom severity groups and coexisting chronic conditions

Design

Longitudinal cohort study across five waves (2011 to 2020)

Authors

BLBowen LiSGSiyu GuanCHChuan Huang

Discussion

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Member takes

Overview

May support depression screening in hypertension/diabetes; leaves open causal cardiovascular and cognitive links in Chinese adults.

Structured PICO

Does depression severity increase the risk of heart disease, stroke, and mental illness in Chinese middle-aged and older adults?

P
Population
13,930 Chinese adults aged 45 and above from the China Health and Retirement Longitudinal Study (CHARLS), without pre-existing cardiovascular disease or mental illness at baseline.
I
Intervention
Higher depression severity (assessed by CES-D-10 scale)
C
Comparator
No depressive symptoms or minimal symptoms (CES-D-10 score 0-5)
O
Outcome
Events of heart disease, stroke, and mental illnesshard clinical

Higher depression severity is significantly associated with an increased risk of heart disease and interacts with chronic conditions to worsen cognitive and life satisfaction outcomes in middle-aged and older Chinese adults.

Limitations

  • Exclusion of economic status and social support due to data limitations or multicollinearity concerns
  • Findings may not be broadly generalizable to non-Chinese populations

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6a7de8d7170912f23a3c99e6https://doi.org/10.3389/fpubh.2025.1530513
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