Key result
Having at least 2 types of chronic diseases combined with depressive symptoms was associated with a 3.000 times higher risk of incident stroke compared to having no chronic disease and no depressive symptoms.
Why the study?
With population aging, multiple chronic diseases, depressive symptoms, and stroke are increasingly common, but their independent and combined associations with incident stroke require prospective evaluation.
Does the combination of multiple chronic diseases and depressive symptoms increase the risk of incident stroke in Chinese middle-aged and elderly adults?
Cohort (n=8,389)
Yes
Does the combination of multiple chronic diseases and depressive symptoms increase the risk of incident stroke in Chinese middle-aged and elderly adults?
Hazard Ratio: 3 (95% CI 1.846–4.877)
Absolute Event Rate: 16.23% vs 3.75%
p-value: p=<0.001
The combination of multiple chronic diseases and depressive symptoms significantly increases the risk of incident stroke in a dose-response manner among middle-aged and elderly Chinese adults.
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Supports screening for depression in multimorbid adults; leaves open whether treatment reduces incident stroke.
Hu et al. (2022) conducted a cohort in Incident stroke (n=8,389). Multiple chronic diseases and depressive symptoms vs. No chronic disease and no depressive symptoms was evaluated on Incident stroke (HR 3.000, 95% CI 1.846-4.877, p=<0.001). Having at least 2 types of chronic diseases combined with depressive symptoms was associated with a 3.000 times higher risk of incident stroke compared to having no chronic disease and no depressive symptoms.
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