Why the study?
Does perinatal loss of insulin signaling in the heart impair mitochondrial function in mice?
Population
8-week-old mice with cardiomyocyte deletion of insulin receptors (CIRKO)
Design
Preclinical
Authors
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Impaired cardiac insulin signaling may promote mitochondrial dysfunction in mice; leaves open its relevance to human heart failure.
Does perinatal loss of insulin signaling in the heart impair mitochondrial function in mice?
Impaired myocardial insulin signaling directly promotes oxidative stress and mitochondrial uncoupling, contributing to cardiac mitochondrial dysfunction independent of systemic metabolic changes.
Boudina et al. (2009) studied this question.
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