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April 29, 2025Cardiology and TherapyOpen Access

At 30 weeks, mavacamten significantly improved lateral E/e' (between-group LSM difference -5.7; 95% CI -7.6 to -3.7, p<0.001), septal E/e' (-5.7; 95% CI -7.8 to -3.7, p<0.001), and LAVI (-8.2 ml/m2; 95% CI -12.0 to -4.4, p<0.001) compared with placebo.

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Why the study?

This exploratory analysis aimed to evaluate the effect of mavacamten on echocardiographic measures of cardiac structure and function and its relationship with other clinical biomarkers in Chinese patients with symptomatic obstructive HCM.

Does mavacamten improve echocardiographic measures of cardiac structure and function in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy?

Population

81 Chinese patients with symptomatic obstructive HCM

Comparison

Mavacamten vs placebo

Design

Exploratory analysis of a randomized controlled trial

Follow-up

30 weeks

Authors

ZTZhuang TianXLXiaoyan LiLLLiwen Li

Discussion

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Overview

Echocardiographic effects of mavacamten in obstructive HCM remain exploratory; leaves open need for confirmatory trials before practice change.

Structured PICO

Does mavacamten improve echocardiographic measures of cardiac structure and function in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy?

P
Population
81 adults (aged ≥18 years) with symptomatic obstructive hypertrophic cardiomyopathy (NYHA class II-III, LVEF ≥55%, peak LVOT gradient ≥50 mmHg at rest or with Valsalva), mean age 51.9 years, 71.6% male, in China.
I
Intervention
Mavacamten for 30 weeks
C
Comparator
Matching placebo for 30 weeks
O
Outcome
Changes in echocardiographic measures of cardiac structure and function (including lateral E/e', septal E/e', and left atrial volume index) from baseline to 30 weekssurrogate

Mavacamten significantly improves echocardiographic measures of cardiac structure and diastolic function, including LV mass index, left atrial volume index, and E/e' ratio, in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy.

Limitations

  • P values and 95% confidence intervals were not adjusted for multiplicity due to the exploratory nature of the analyses

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/6a7de8e8432a20ae7c150d9ahttps://doi.org/10.1007/s40119-025-00409-5
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