May 27, 2025Indian Heart JournalOpen Access

The effect of mavacamten on echocardiographic parameters, cardiac function and biomarkers in hypertrophic cardiomyopathy patients, a systematic review and meta-analysis

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Why the study?

To evaluate the effect of mavacamten on echocardiographic parameters and cardiac biomarkers in patients with hypertrophic cardiomyopathy.

Does mavacamten improve echocardiographic parameters and cardiac biomarkers in patients with hypertrophic cardiomyopathy?

Comparison

Mavacamten therapy

Design

Systematic review and meta-analysis

Authors

ZOZina OtmaniMouloud Mammeri University of Tizi-Ouzou NANoura AbdrabouAlexandria University HEHosam F. El-SayedEastern Virginia Medical School

Discussion

Member takes

Implication

Supports mavacamten in obstructive HCM for diastolic and biomarker gains; extends trial data via pooled surrogates.

Structured PICO

Does mavacamten improve echocardiographic parameters and cardiac biomarkers in patients with hypertrophic cardiomyopathy?

Population

7 studies pooling 524 patients with hypertrophic cardiomyopathy (456 with obstructive HCM and 59 with non-obstructive HCM)

Intervention

Mavacamten

Outcome

Echocardiographic parameters (septal e', LVMI, LVOT gradient, LAVI, E/e' ratios) and cardiac biomarkers (NT-proBNP, troponin)surrogate

Mavacamten significantly improves surrogate echocardiographic and biomarker profiles in patients with hypertrophic cardiomyopathy, particularly the obstructive subtype.

Limitations

Limited data on non-obstructive HCM

Cite This Study

Otmani et al. (2025) studied this question.

synapsesocial.com/papers/6a7e223c5173b4fd5be96fd1 https://doi.org/10.1016/j.ihj.2025.05.011

Topics

Echocardiography Hypertrophic cardiomyopathy

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The effect of mavacamten on echocardiographic parameters, cardiac function and biomarkers in hypertrophic cardiomyopathy patients, a systematic review and meta-analysis

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

The effect of mavacamten on echocardiographic parameters, cardiac function and biomarkers in hypertrophic cardiomyopathy patients, a systematic review and meta-analysis

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider