What question did this study set out to answer?

To address statistical challenges in evaluating changes in microfilarial load after chemotherapeutic treatment and establish a dose-response profile for diethylcarbamazine in onchocerciasis.

January 1, 1987Annals of Tropical Medicine and Parasitology

The chemotherapy of onchocerciasis

View Full Paper

Ask AI

Bookmark

Authors

AFAnthony J. C. FulfordUniversity of Cambridge SMSarah MacfarlaneUniversity of Dundee KAK. AwadziNovartis (Switzerland)

Discussion

Member takes

Implication

Pooled regression analysis demonstrates post-treatment microfilarial load dynamics in onchocerciasis patients, suggesting optimal dose-response relationships for diethylcarbamazine.

Key Points

To address statistical challenges in evaluating changes in microfilarial load after chemotherapeutic treatment and establish a dose-response profile for diethylcarbamazine in onchocerciasis.
Pooled and analyzed data across 10 distinct diethylcarbamazine (DEC) clinical trials conducted at the Onchocerciasis Chemotherapeutic Research Centre between 1978 and 1983.
Fitted regression models of post-treatment microfilarial loads across multiple time intervals incorporating baseline microfilarial load, cumulative DEC dose, treatment duration, and patient age as independent variables.
Assessed underlying model assumptions and determined optimal variable transformations through residual plot analyses.
Characterized post-treatment microfilarial clearance patterns as a function of baseline microfilarial load, treatment duration, cumulative drug dose, and patient age using transformed regression models.
Constructed an empirical dose-response curve for diethylcarbamazine relating total administered dose to the extent of microfilarial load reduction.

Cite This Study

Fulford et al. (1987) studied this question.

synapsesocial.com/papers/6a7de8ec4776ec6335187a96 https://doi.org/10.1080/00034983.1987.11812173

View Full Paper

Ask AI

Bookmark

Implication

Pooled regression analysis demonstrates post-treatment microfilarial load dynamics in onchocerciasis patients, suggesting optimal dose-response relationships for diethylcarbamazine.

The chemotherapy of onchocerciasis

Discussion

Member takes

Implication

Key Points

Cite This Study

The chemotherapy of onchocerciasis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider