The Occurrence of Carcinoma in "Hot" Thyroid Nodules

Case Studies1 May 1963The Occurrence of Carcinoma in "Hot" Thyroid NodulesReport of Two CasesFRANK O. BECKER, M.D., PETER G. ECONOMOU, M.D., THEODORE B. SCHWARTZ, M.D., F.A.C.P.FRANK O. BECKER, M.D.Search for more papers by this author, PETER G. ECONOMOU, M.D.Search for more papers by this author, THEODORE B. SCHWARTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-877 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen the physician finds a patient with nodular goiter, he must consider the possibility of malignancy and decide whether surgery is indicated. Surgeons, generally, have found that the incidence of carcinoma in nodular goiter is high and recommend immediate surgery (1-5). Internists (6-8), on the other hand, conclude the incidence is low and in most instances suggest medical management.With regard to solitary nodules, the advent of the scintogram has led to more agreement of opinion. This technique permits a qualitative distinction between hyperfunctioning ("hot") and hypofunctioning ("cold") nodules. Means (9), in 1950, stated: "So far we have never found...References1. COPEDOBYNSHAMLINHOPKIRK OBMEJ: What thyroid nodules are to be feared? J. Clin. Endocr. 9: 1012, 1949. CrossrefGoogle Scholar2. SLOAN LW: Some surgical problems of non-toxic goiter. J. Clin. Endocr. 10: 1092, 1950. CrossrefGoogle Scholar3. CERISESPEARSOCHSNER EJRA: Carcinoma of the thyroid and non-toxic nodular goiter. Surgery 31: 552, 1952. MedlineGoogle Scholar4. MAJURAKISSLAUGHTERCOLE JDDPWH: Carcinoma of the thyroid gland. J. Clin. Endocr. 13: 1530, 1953. CrossrefGoogle Scholar5. RAVDIN RG: Cancer of the thyroid. Amer. J. Med. Sci. 227: 201, 1954. CrossrefMedlineGoogle Scholar6. VANDERLAAN WP: Occurrence of carcinoma of thyroid gland in autopsy material. New Engl. J. Med. 237: 221, 1947. CrossrefMedlineGoogle Scholar7. ROGERSASPERWILLIAMS WFSPRH: Clinical significance of malignant neoplasms of thyroid gland. New Engl. J. Med. 237: 569, 1947. CrossrefMedlineGoogle Scholar8. GREERASTWOOD MAEB: Treatment of simple goiter with thyroid. J. Clin. Endocr. 13: 1312, 1953. CrossrefGoogle Scholar9. MEANS JH: Thyroidology 1950, The Pharos November, 1951. Google Scholar10. PERLMUTTERSLATER MSL: Which nodular goiters should be removed? New Engl. J. Med. 255: 65, 1956. CrossrefMedlineGoogle Scholar11. FRIEDELL MT: Radioactive iodine in management of solitary thyroid nodules. Trans. Amer. Goiter Ass. (1952): 165, 1953. Google Scholar12. SUSSMAN ML: Laboratory study of thyroid function. Arizona Med. 12: 153, 1955. MedlineGoogle Scholar13. JOHNSONBIERWALTES PCWH: Reliability of scintiscanning nodular goiters in judging presence or absence of carcinoma. J. Clin. Endocr. 15: 865, 1955. Google Scholar14. GROESBECK HP: Evaluation of routine scintiscanning of non-toxic thyroid nodules. I. Preoperative diagnosis of thyroid carcinoma. Cancer 12: 1, 1959. CrossrefMedlineGoogle Scholar15. MOLNARCHILDSWOOLNER GDDSLB: Histologic evidence of malignancy in a thyroid gland bearing a "hot" nodule. J. Clin. Endocr. 18: 1132, 1958. CrossrefGoogle Scholar16. MEADOWS PM: Scintillation scanning in the management of the clinically single thyroid nodule. JAMA 177: 229, 1961. CrossrefMedlineGoogle Scholar17. WERNERSPOONER SCM: A new and simple test for hyperthyroidism employing 1-tri-iodothyronine and the twenty-four hour I-131 uptake method. Bull. NY Acad. Med. 31: 137, 1955. MedlineGoogle Scholar18. SHELINEMCCORMACK GEK: Solitary hyperfunctioning thyroid nodules. J. Clin. Endocr. 20: 1401, 1960. CrossrefGoogle Scholar19. FITZPATRICKFOOTE PJFW: The function of various types of thyroid carcinoma as revealed by the radioautographic demonstration of radioactive iodine. J. Clin. Endocr. 9: 1153, 1949. CrossrefGoogle Scholar20. BLACKWOOLNERBLACKBURN BMLBCM: The uptake of radioactive iodine by carcinoma of the thyroid gland. J. Clin. Endocr. 13: 1378, 1953. CrossrefGoogle Scholar21. SHIMAOKABADILLOSOKALMARCHETTA KJJEFC: Clinical differentiation between thyroid cancer and benign goiter. JAMA 181: 179, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRANK O. BECKER, M.D.; PETER G. ECONOMOU, M.D.; THEODORE B. SCHWARTZ, M.D., F.A.C.P.Affiliations: Chicago, IllinoisDoctor Becker is a trainee of the United States Public Health Service.Requests for reprints should be addressed to Theodore B. Schwartz, M.D., Section of Endocrinology and Metabolism, Presbyterian-St Luke's Hospital, 1753 West Congress Parkway, Chicago, Illinois. 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Diagnostic Use of RadioiodineNeuere Gesichtspunkte zur Diagnostik und Therapie der Struma maligna 1 May 1963Volume 58, Issue 5Page: 877-882KeywordsAdenomasMedical servicesSurgeonsSurgeryThyroidThyroid carcinoma ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...