Renal-Dose Dopamine: Fact and Fiction

Editorials15 July 1991Renal-Dose Dopamine: Fact and FictionHarold M. Szerlip, MDHarold M. Szerlip, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-2-153 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeriously ill patients commonly show inadequate urine output or deteriorating renal function during a stay in an intensive care unit. When confronted by such events, the critical care specialist often resorts to infusions of dopamine at "renal doses." Accordingly, dopamine has become one of the most commonly used drugs in both medical and surgical intensive care units. It is considered a panacea for oliguria and a mithridate against renal failure. Unfortunately, the mystique that surrounds dopamine's effectiveness in these situations is largely based on anecdotal reports and poorly controlled studies. This is not to say that renal-dose dopamine has no...References1. HorwitzFoxGoldberg DSL. Effects of dopamine in man. Circulation Res. 1962;10:237-43. CrossrefMedlineGoogle Scholar2. McDonaldGoldbergMcNayTuttle RLJE. Effects of dopamine in man: augmentation of sodium excretion, glomerular filtration rate, and renal plasma flow. J Clin Invest. 1964;43:1116-24. CrossrefMedlineGoogle Scholar3. KebabianCalne JD. Multiple receptors for dopamine. Nature. 1979;277:93-6. CrossrefMedlineGoogle Scholar4. SchwartzGewertz LB. The renal response to low dose dopamine. J Surg Res. 1988;45:574-88. CrossrefMedlineGoogle Scholar5. ter WeeSmitRosmanSluiterDonker PAJWJ. Effect of intravenous infusion of low-dose dopamine on renal function in normal individuals and in patients with renal disease. Am J Nephrol. 1986;6:42-6. CrossrefMedlineGoogle Scholar6. OlsenHansenLadefogedFogh-AndersenLeyssac NJSNP. Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man. Clin Sci. 1990;78:503-7. CrossrefMedlineGoogle Scholar7. Seri I. Dopamine and natriuresis mechanism of action and developmental aspects. Am J Hypertens. 1990;3:82S-6S. MedlineGoogle Scholar8. OrmeBreckenridgeDollery MAC. The effects of long term administration of dopamine on renal function in hypertensive patients. Eur J Clin Pharmacol. 1973;6:150. CrossrefMedlineGoogle Scholar9. GoldbergMcDonaldZimmerman LRA. Sodium diuresis produced by dopamine in patients with congestive heart failure. N Engl J Med. 1963;269:1060-4. CrossrefMedlineGoogle Scholar10. BeregovichBianchiRublerLomnitzCaginLevitt JCSENB. Dose-related hemodynamic and renal effects of dopamine in congestive heart failure. Am Heart J. 1974;87:550-7. CrossrefMedlineGoogle Scholar11. Szerlip H. Sodium and volume homeostasis. In: Carlson RW, Geheb MA, eds. Principles and Practice of Medical Intensive Care. Philadelphia: W. B. Saunders; [In press]. Google Scholar12. HendersonBeattieKennedy ITA. Dopamine hydrochloride in oliguric states. Lancet. 1980;2:827-9. CrossrefMedlineGoogle Scholar13. ParkerCarlonIsaacsHowlandKahn SGMWR. Dopamine administration in oliguria and oliguric renal failure. Crit Care Med. 1981;9:630-2. CrossrefMedlineGoogle Scholar14. Lindner A. Synergism of dopamine and furosemide in diuretic-resistant oliguric acute renal failure. Nephron. 1983;33:121-6. CrossrefMedlineGoogle Scholar15. GrazianiCantaluppiCasati GAS. Dopamine and frusemide in oliguric acute renal failure. Nephron. 1984;37:39-42. CrossrefMedlineGoogle Scholar16. SchaerFinkParrillo GMJ. Norepinephrine alone versus norepinephrine plus low-dose dopamine: enhanced renal blood flow with combination pressor therapy. Crit Care Med. 1985;13:492-6. CrossrefMedlineGoogle Scholar17. CassonClaydenCopeLee IDGM. The protective effect of y-glutamyl L-dopa on the glycerol treated rat model of acute renal failure. Clin Sci. 1983;65:159-64. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Harold M. Szerlip, MDAffiliations: Philadelphia Veterans Affairs Medical Center University of Pennsylvania School of Medicine Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKidney Function Reserve Capacity in Early and Later Stage Autosomal Dominant Polycystic Kidney DiseaseAcute Kidney Injury (AKI) Clinical Trials: A Critical AppraisalSurgery in the patient with renal diseaseClinical Assessment of Renal FunctionUse of dopamine in acute renal failureEffect of low-dose dopamine on sigmoid colonic intramucosal pH in patients undergoing elective abdominal aortic aneurysm repairRenal-Dose Dopamine: From Hypothesis to Paradigm to Dogma to Myth and, Finally, Superstition?Low-Dose Dopamine: It’s Like Déjà Vu All Over AgainDopamine-1 Receptor Agonist: Renal Effects and Its Potential Role in the Management of Radiocontrast-Induced NephropathyEffects of low-dose dopamine on ventilation in patients with chronic obstructive pulmonary diseaseAcute Renal Failure in the Critically Ill Patient: Is there a Magic Bullet?Acute Renal Failure in the Critically Ill Patient: Is there a Magic Bullet?OliguriaAcute Rental Failure and Dialysis in the Chronically Critically Ill PatientAcute Renal Failure: A Practical UpdateRenal-dose dopamine: will the message now get through?Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trialRenal dose dopamine: Long on conjecture, short on factDie akute respiratorische Insuffizienz im Rahmen des multiplen OrgandysfunktionssyndromsThe renal effect of low-dose dopamine in high-risk patients undergoing coronary angiographyLow-dose dopamine does not prevent acute renal failure in patients with septic shock and oliguriaDirect Effects of Dopamine on Colonic Mucosal pH: Implications for TonometryDiuretic TherapyAcute Renal Failure: Focus on Advances in Acute Tubular NecrosisEdematous StatesEndothelial dysfunction in acute renal failureHemodynamic factors influencing renal blood flowJust how benign is renal dopamine?Circulatory Support, Dopamine, and Dopamine Agonists as Adjuncts to Diuretic TherapyIs the Administration of Dopamine Associated with Adverse or Favorable Outcomes in Acute Renal Failure?IS RENAL DOSE DOPAMINE PROTECTIVE OR THERAPEUTIC? NO“Renal-dose” dopamine for the treatment of acute renal failure: Scientific rationale, experimental studies and clinical trialsThe changing pattern of severe acute renal failureAcute Renal FailureRenal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholaminesProphylaxis and Conservative Management of Acute Renal Failure in the ICUProphylaxe und Therapie der akuten respiratorischen Insuffizienz im Rahmen des multiplen OrgandysfunktionssyndromsNew Aspects of Acute Renal FailureLow-Dose Dopamine in Severe Right Heart Failure and Chronic Obstructive Pulmonary DiseaseRenovascular interaction of epinephrine, dopamine, and intraperitoneal sepsisSome Recent Controversies in Intensive CareDopaminergic Drugs in Cardiovascular EmergenciesPrevention of Acute Renal Failure in the Critically Ill PatientClinical Uses of DiureticsIs low-dose dopamine or furosemide useful in cardiac surgical patients ?Serum Aldosterone Concentrations and Urine Output in Oliguric Intensive Care Unit Patients Receiving Low-Dose DopamineWhich inotropic agent?Selected complications of allogeneic bone marrow transplantationPharmacologic Management of Shock-Induced Renal DysfunctionCatecholamines in critical careHerz-Kreislauftherapie bei Patienten mit MultiorganversagenAkutes Nierenversagen und Nierenersatzverfahren 15 July 1991Volume 115, Issue 2Page: 153-154KeywordsCritical careDopamineDrugsIntensive care unitsMedical servicesRenal critical careRenal failureSurgical intensive care unitsUrine ePublished: 1 December 2008 Issue Published: 15 July 1991 PDF downloadLoading ...